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Causes of peritoneal mesothelioma cancer

Pleural mesothelioma, pericardial mesothelioma, testicular mesothelioma, and peritoneal mesothelioma cancer are the four different kinds of mesothelioma cancer. Your abdomen and pelvis are covered by a thin membrane that develops peritoneal mesothelioma. The peritoneum is the common name for this thin membrane. Consequently, malignant peritoneal mesothelioma cancer is the name given to cancer that develops on the peritoneum.

There are two layers within the peritoneum itself: the inner layer and the outer layer. The visceral peritoneum, another name for the inner layer, covers the surface of the ovaries, liver, and colon in your belly. The walls of your abdomen and pelvis are lined by the outer parietal peritoneum.

In most cases, a thin liquid film separates the two layers. As you walk, the two layers can slide around thanks to this liquid. However, there is frequently an excessive buildup of fluid between the layers of the peritoneum in persons with peritoneal mesothelioma cancer.

As already noted, asbestos exposure over a lengthy period of time is the primary cause of malignant peritoneal mesothelioma cancer. Several cases, nevertheless, suggested that this malignancy is unrelated to asbestos. An illustration of this can be found in a 1975 research on a community in Turkey’s central Cappadocia. The study demonstrates that a genetic susceptibility to mineral fiber carcinogenesis was the main contributor to peritoneal mesothelioma in the hamlet.

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But such results only apply to particular instances in that field. The highest mesothelioma rates can be found in places like Australia. Asbestos exposure is the primary cause of peritoneal mesothelioma cancer in the US. In the US, about 1000 cases are found each year. Most of the patients had previously worked in fields connected to asbestos, including construction, mining, and cement production.

It may take years for malignant peritoneal mesothelioma cancer to manifest. The majority of asbestos patients are between 60 and 70 years old because of the prolonged latency period. However, younger people might also be diagnosed with this type of cancer. Fibers from asbestos inhaled could irritate and inflame the abdomen.

The fibers may also affect normal cellular functions by destabilizing chromosomes. Tumors may eventually form as a result of these damages. The following are the most typical signs of peritoneal mesothelioma cancer:

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Even though the patient may feel some of the typical peritoneal mesothelioma symptoms, a doctor must still make the correct diagnosis. In addition, getting the diagnosis from a peritoneal mesothelioma cancer specialist is advised. This is a result of the frequent instances of misdiagnosis. Due to the rarity of this malignancy, clinicians sometimes confused it with more prevalent cancers that had comparable symptoms.

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Peritoneal mesothelioma is identified in stages, just as other cancers. Imaging tests like CT scans and X-rays are frequently used in the first stage of diagnosis. The doctor will next ask for a blood test in the following phase. To find particular biomarkers linked to the cancer, a blood test is required. A doctor will eventually need to do biopsies to confirm the cancer.

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By gathering the accumulated fluid on the patient’s peritoneal membrane, biopsies are carried out. In addition, this technique is used to obtain the tissue sample. This procedure is required to determine the cancer’s cell type and its stage of development.
The stage of cancer will also be determined by the doctor during the diagnosis. There is no established staging method for peritoneal mesothelioma, unlike pleural mesothelioma. Despite this, the PCI system still allows clinicians to categorize cancer according to specific criteria. The most popular technique for peritoneal mesothelioma staging is PCI (Peritoneal Cancer Index).

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The patient’s abdomen is divided into 13 parts using this technique. Based on the existence of tumors, each region is graded on a scale from 0 to 3. The tumor has spread farther when the score is greater. The overall score is tallied after the test has ended. This approach yields a maximum score of 39. If the score is high, it means the patient’s peritoneal mesothelioma cancer has progressed to an advanced stage.

There is a different technique for peritoneal mesothelioma staging in addition to the PCI. The stage of peritoneal mesothelioma is frequently determined using the Tumor Node Metastasis (TNM) approach. According to a research study published in 2020, numerous oncologists have modified the TNM system to divide peritoneal mesothelioma into three stages.

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